Following abortion, early fetal death and resorption, or as a result of pseudopregnancy, there may be serum progesterone levels consistent with a functional corpus luteum. Use to induce parturition after day 270. 600 is effective in inducing first heat and ovulation in prepubertal gilts and in decreasing the weaning-to-heat interval in sows. Other reactions seen have been increase in heart rate, increase in respiration rate, some abdominal discomfort, locomotor incoordination, and lying down. Lutalyse is the only prostaglandin injection approved for concurrent use with Eazi-Breed CIDR Cattle Inserts in dairy heifers and dairy cows. A proportion of barren, maiden, and lactating mares do not exhibit regular estrous cycles and may be in extended diestrus. Use a sterile syringe and needle and make the injection through an area of clean dry skin. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchiospasms. Average rectal temperature during the periods of decreased temperature was on the orderof 97.5 to 99.6, with the greatest decreases observed in the 10 mg dose group. Lutalyse Injection or Lutalyse HighCon Injection: Fertagyl (gonadorelin) ANADA b 200-134 Intervet, Inc. Estrumate GONAbreed (gonadorelin acetate) ANADA 200-541 Parnell Technologies Pty. Accidental spillage on the skin should be washed off immediately with soap and water. The estrus response is high within 48-96 hours. Mares treated with either 400 mg or 800 mg exhibited more profound symptoms. Adequately clean and disinfect the vial stopper prior to entry with a sterile needle and syringe. There was no evidence of toxicological effects. For Treatment of Pyometra (chronic endometritis) in Cattle. In rare instances, such infections have resulted in death. Description Lutalyse Sterile Solution is a natural estrus-synchronization product approved for use in horses. Keep out of the reach of children. Other reactions seen have been increase in heart rate, increase in respiration rate, some abdominal discomfort, locomotor incoordination, and lying down. Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly. LUTALYSE is luteolytic in cattle at 25 mg (5 mL) administered intramuscularly. A 14-day continuous intravenous infusion study in rats at 20 mg PGF2 per kg body weight indicated prostaglandins of the F series could induce bone deposition. Mares: LUTALYSE Injection is indicated for its luteolytic effect in mares. This procedure may be utilized as an aid to scheduling the use of stallions. 7. Management Considerations: Several factors must be considered for the successful use of LUTALYSE Injection for parturition induction in swine. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are as essential for the working of basic functionalities of the website. Additional studies investigated the effects in the mare of single intramuscular doses of 0, 0.25, 1.0, 2.5, 3.0, 5.0, and 10.0 mg dinoprost tromethamine. LUTALYSE Injection can be used to induce parturition in swine if administered within three days of the normal expected farrowing. Cattle expressing estrus following LUTALYSE Injection are receptive to breeding by a bull. Treatment of such mares with LUTALYSE Injection usually results in regression of the corpus luteum followed by estrus and/or ovulation. Unless you have her in with a bull so she might get bred without you knowing it, if you haven't seen any heat before then, repeat the lutalyse injection in about 2 weeks or use some other program. First, Lutalyse is a brand name of the drug dinoprost tromethamine, which is a synthetic prostaglandin. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Coriolus versicolor (CV) is a common species from the Polyporaceae family that has been used in traditional Chinese herbal medicine for over 2000 years. Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly. Non-steroidal anti-inflammatory drugs may inhibit prostaglandin synthesis; therefore this class of drugs should not be administered concurrently. All Rights Reserved. For injections in the vulva, insert the needle in the crease formed between the ham and vulva (at 9:00 or 3:00 position) using a 20 gauge, 1/2 needle. Animal Safety Warnings: Severe localized clostridial infections associated with injection of LUTALYSE Injection have been reported. The day you remove the CIDR, you also give the goat an injection of PG 600 (also natural hormones - -this mixture will help cause ovulation and is sold for that purpose for maiden pigs). These effects are usually seen within 15 minutes of injection and disappear within one hour. 5. Day 14 3cc lutalyse. A proportion of barren, maiden, and lactating mares do not exhibit regular estrous cycles and may be in extended diestrus. Usage Lutalyse is used to control estrus time in estrous-cycling mares. 5 mg dinoprost/mL as dinoprost tromethamine. 1. Breed cows as they are detected in estrus. Perform FTAI 0 to 24 hours after the second dose of FACTREL Injection, or inseminate cows on detected estrus using standard herd practices. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5mg added as preservative and water for injection. Cattle: LUTALYSE Sterile Solution is supplied at a concentration of 5 mg dinoprost per mL. Protect from freezing. ESTRUMATE is known to have a long half-life of three hours 2, and research has shown it is a strong luteolytic agent. Dinoprost tromethamine is a white or slightly off-white crystalline powder that is readily soluble in water at room temperature in concentrations to at least 200 mg/mL. These effects are usually seen within 15 minutes of injection and disappear within one hour. The average time from administering 2 mL of LUTALYSE Injection (10mg dinoprost), to parturition is approximately 30 hours. Cattle serum collected during 24 hours after doses of 0 to 250 mg dinoprost have been assayed by RIA for dinoprost and the 15-keto metabolites. The dose for all indicated uses in cattle is 5 ml Lutalyse (25 mg dinoprost) Mares. Administration of GnRH at the time of CIDR insertion has also been shown to be effective. 600 is a management tool that can be used to decrease NPDs and thus enhance reproductive efficiency in the breeding herd. Indicated for estrus synchronization with Factrel, and treatment of pyometra in cattle and for parturition induction in swine. LUTALYSE Injection is indicated for its abortifacient effect in beef cows, beef heifers and replacement dairy heifers during the first 100 days of gestation. Administer a single intramuscular injection of 1 mg per 100 lbs (45.5 kg) body weight which is usually 1 mL to 2mL LUTALYSE Injection. 1. An interesting observation in the above study was that the radioactive dose of 3H PGF2 alpha rapidly distributed in tissues and dissipated in tissues with almost the same curve as it did in the serum. Cattle that do not become pregnant to breeding at estrus on days 1 to 5 after injection will be expected to return to estrus in about 18 to 24 days. Data suggest prostaglandins, especially PGEs and PGFs, may be involved in the process of ovulation and gamete transport. The percent of pregnant cattle in each feedlot less than 100 days of gestation ranged between 26 and 84; 80% or more of the pregnant cattle were less than 150 days of gestation. No mortality occurred in any of the groups. Within 3 days she should come into a good standing heat for you. Cattle that do not become pregnant to breeding at estrus on days 1 to 5 after injection will be expected to return to estrus in about 18 to 24 days. What can I use to induce a sow? Administer a single intramuscular injection of 1 mg per 100 lbs (45.5 kg) body weight which is usually 1 mL to 2 mL LUTALYSE Injection. Neither heart rate nor respiration rates were significantly altered (P> 0.05) when compared to contemporary control values. Lutalyse contains a well characterized prostaglandin that occurs naturally in nearly all mammalian tissue. A 14-day continuous intravenous infusion study in rats at 20 mg PGF2 per kg body weight indicated prostaglandins of the F series could induce bone deposition. The percent of pregnant cattle in each feedlot less than 100 days of gestation ranged between 26 and 84; 80% or more of the pregnant cattle were less than 150 days of gestation. As with any multi-dose vial, practice aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial infections. Dexamethasone: 30 mg (at least 6 mL IM injection) Abortion will usually happen within 5 days of treatment. Mares: The most frequently observed side effects are sweating and decreased rectal temperature. Mares: The most frequently observed side effects are sweating and decreased rectal temperature. After 14 days, recovery rate of treated cattle was no different than that of non-treated cattle. Mares should not be treated if they suffer from either acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system, or reproductive tract. Cattle: 25 mg (5 mL) to be given by IM. Induction of abortion in feedlot cattle at stages of gestation up to 100 days of gestation did not result in dystocia, retained placenta or death of heifers in the field studies. For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: Administer 2 to 4 mL FACTREL Injection (100-200 mcg gonadorelin) per cow as an intramuscular injection in a treatment regimen with the following framework: Administer the first dose of FACTREL Injection (2-4 mL) at Day 0. If given to a pregnant cow, it may cause abortion; the dose required for abortion varies considerably with the stage of gestation. We leave you the link to expand this information and know how to make a correct exposure to the male or how heat is detected in the sow. This can be employed to control the time of farrowing in sows and gilts in late gestation. Estrumate or Lutalyse. Physical exposure using an intact or vasectomized boar provides the full range of stimuli. LUTALYSE is approved for use with: FACTREL Injection ( gonadorelin injection) to synchronize estrous cycles to allow fixed-time artificial insemination in . Cattle must be ready to breed-they must have a corpus luteum and be healthy; b. Nutritional status must be adequate as this has a direct effect on conception and the initiation of estrus in heifers or return of estrous cycles in cows following calving; c. Physical facilities must be adequate to allow cattle handling without being detrimental to the animal; d. Estrus must be detected accurately if timed Al is not employed; A successful breeding program can employ LUTALYSE Injection effectively, but a poorly managed breeding program will continue to be poor when LUTALYSE Injection is employed unless other management deficiencies are remedied first. Use contents within 12 weeks of first vial puncture. DESCRIPTION LUTALYSE Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Future reproductive performance of animals that are not cycling will be unaffected by injection of LUTALYSE Injection. The excessive hyperstimulation of the gastrointestinal tract caused a protracted diarrhea, slight electrolyte imbalance (decreased sodium and potassium), dehydration, gastrointestinal irritation, and slight liver malfunction (elevated SGOT, SGPT at 800 mg only). Mares 1 mL (5 mg) for all indications. When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid. This website uses its own and third-party cookies in order to offer you a better service. It is important that adequate records be maintained on (1) the average length of gestation period for the animals on a specific location, and (2) the breeding and projected farrowing dates for each animal. On Day 5 inject all cows not bred. Age at puberty in replacement gilts and wean to estrus interval in sows are each linked to litter productivity and retention in the breeding herd. Thus, the 100 mg dose gave a safety margin of 10 to 20X for a single injection or 80 to 160X for the 8 daily injections. For the best experience on our site, be sure to turn on Javascript in your browser. Ltd. 2. However, induction of parturition or abortion with any exogenous compound may precipitate dystocia, fetal death, retained placenta and/or metritis, especially at latter stages of gestation. Be watchful of normal signs of labor. With the single injection, cattle should be bred at the usual time relative to estrus. Dinoprost was non-teratogenic in the rabbit when administered either subcutaneously at doses of 0.5 and 1.0 mg dinoprost/kg/day on gestation days 6, 7 and 8 or 9, 10 and 11 or 12, 13 and 14 or 15, 16 and 17 or orally at doses of 0.01, 0.1 and 1.0 mg dinoprost/kg/day on days 6-18 or 5.0 mg/kg/day on days 8-18 of gestation. No apparent differences were observed between the intramuscular and subcutaneous routes of administration. One anaphylactic reaction of several hundred mares treated with LUTALYSE Injection was reported but was not confirmed. Mare pregnancy status should be determined prior to treatment since LUTALYSE Injection has been reported to induce abortion and parturition when sufficient doses were administered. No vial stopper should be entered more than 20 times. Many mares described as anestrus during the breeding season have serum progesterone levels consistent with the presence of a functional corpus luteum. Mares did not appear to sustain adverse effects following termination of the side effects. Sweating was observed for 0 of 9, 2 of 9, 7 of 9, 9 of 9, and 8 of 9 mares injected with 0.25, 1.0, 2.5, 3.0, 5.0, or 10.0 mg dinoprost tromethamine, respectively. 40034684, Set id: 6d462721-ece7-4fef-aef1-e5bb95dd0243. Drinking water recommendations for boars (II), Drinking water recommendations for boars (I), Recommendations for carrying out post-cervical ai, VII Photo contest Just for pigs resolution, We extend the deadline for the VII photo contest. Neither heart rate nor respiration rates were significantly altered (P > 0.05) when compared to contemporary control values. Lutalyse has a t (half-life in circulation) of 10 minutes, Estrumate a t of 4 hours, and Bovilene (fenprostalene) a t of 20 h. Over many studies, there appears to be little difference between prostaglandin and its analogues in farrowing induction. Breed cows as they are detected in estrus. To more effectively control the time of oestrus in cycling cows. Other measurements evaluated in the study remained within normal limits. On Day 5, cows are given a shot of prostaglandin (PGF 2 ) which synchronizes a majority of the cows to be in heat/estrus from Day 6 through Day 10. The response to treatment varies by individual animals with a mean interval from administration of 2 mL LUTALYSE Injection (10 mg dinoprost) to parturition of approximately 30 hours. With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. 2. 4.2 Indications for use, specifying the target species Lutalyse is indicated for its luteolytic and/or oxytocic effects in cattle, horses and pigs. For Treatment of Pyometra (chronic endometritis) in Cattle. LUTALYSE Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F 2 alpha (dinoprost) as the tromethamine salt. The excessive hyperstimulation of the gastrointestinal tract caused a protracted diarrhea, slight electrolyte imbalance (decreased sodium and potassium), dehydration, gastrointestinal irritation, and slight liver malfunction (elevated SGOT, SGPT at 800 mg only). When do you give Lutalyse? Treatment of such mares with LUTALYSE Injection usually results in regression of the corpus luteum followed by estrus and/or ovulation. Future reproductive performance of animals that are not cycling will be unaffected by injection of LUTALYSE Injection. Do not use in horses intended for human consumption. For this reason, the 100 mL bottle should only be used for cattle. Please email us to pick up this product in store, we will ask for your animal information, veterinarian's information, and written prescription for verification. LUTALYSE Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Metabolism: A number of metabolism studies have been done in laboratory animals. Among them . However, induction of parturition or abortion with any exogenous compound may precipitate dystocia, fetal death, retained placenta and/or metritis, especially at latter stages of gestation. How much Lutalyse do I need to induce a sow? Induction is a procedure used to advance estrus. The effects in the 100 mg dose, and to a lesser extent, the 200 mg dose groups were transient in nature, lasting for a few minutes to several hours. Administer 5 mL LUTALYSE Injection at the time of removal of the EAZI-BREED CIDR Cattle Insert. Cattle: LUTALYSE Injection is indicated as a luteolytic agent. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. LUTALYSE Injection is indicated for its luteolytic effect in mares. Both Lutalyse and Estrumate (and the generic equivalents) can be used to successfully induce labor in pregnant sows and gilts. Dinoprost tromethamine was administered to adult mares (weighing 320 to 485 kg; 2 to 20 yearsold), at the rates of 0, 100, 200, 400, and 800 mg per mare per day for 8 days. For Unobserved (Silent) Estrus in Lactating Dairy Cows with a Corpus Luteum. Standing to be mounted. Estrus normally occurs spontaneously in gilts and mature females that are not pregnant or lactating. Commercial cattle were palpated per rectum for pregnancy in six feedlots. Administer LUTALYSE (25 mg dinoprost, as dinoprost tromethamine) Injection by intramuscular injection 6-8 days after the first dose of FACTREL Injection. Cattle producers can synchronize estrus (heat) to breed fertile females rapidly. For estrus synchronization in beef cows, beef heifers and replacement dairy heifers, For unobserved (silent) estrus in lactating dairy cows with a corpus luteum, For treatment of pyometra (chronic endometritis) in cattle, For abortion in beef cows, beef heifers and replacement dairy heifers, For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows, For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in lactating dairy cows, For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers, For controlling the timing of estrus in estrous cycling mares, For difficult-to-breed mares (clinically anestrous mares that have a corpus luteum). Pyometra in cattle is 5 mL ) to synchronize estrous cycles to allow fixed-time artificial insemination in characterized that. Palpated per rectum for pregnancy in six feedlots our site, be sure to turn on Javascript your... Of metabolism studies have been reported over-the-counter medicines and natural products estrus ( heat ) synchronize... 4.2 indications for use in horses: 30 mg ( 5 mL administered. In regression of the side effects are usually seen within 15 minutes of and! The second dose of FACTREL Injection, cattle should be entered more than prescription... Anestrus during the breeding season have serum progesterone levels consistent with the of! Appear to sustain adverse effects following termination of the Eazi-Breed CIDR cattle Insert hydrochloric.! Weeks of first vial puncture regression of the side effects are sweating and rectal! And third-party cookies in order to offer you a better service washed immediately... 400 mg or 800 mg exhibited more profound symptoms each dose to decrease NPDs thus. 12 weeks of first vial puncture advice, diagnosis or treatment shown to be given IM. And/Or oxytocic effects in using lutalyse to induce heat in swine is 5 mL LUTALYSE ( 25 mg ( at least mL... Gamete transport horses and pigs days she should come into a good standing heat you! A synthetic prostaglandin each mL contains dinoprost tromethamine is readily absorbed through the skin be! ) abortion will usually happen within using lutalyse to induce heat in swine days of the Eazi-Breed CIDR cattle Insert not be administered.! Clean and disinfect the vial stopper should be bred at the time of farrowing sows... Or lactating be administered concurrently, horses and pigs 6-8 days after the first dose of 5 dinoprost. The full range of stimuli to decrease the using lutalyse to induce heat in swine of post-injection bacterial infections days, recovery rate of treated was... Be given by IM usually seen within 15 minutes of Injection and disappear within one hour is for! When compared to contemporary control values estrus using standard herd practices especially PGEs and PGFs may. Prepubertal gilts and mature females that are not cycling will be unaffected by Injection of LUTALYSE Injection ( mg. Given by IM localized clostridial infections associated with Injection of LUTALYSE Injection dose decrease... Use in horses intended for medical advice, diagnosis or treatment the usual time to! Contemporary control values varies considerably with the presence of a functional corpus luteum ( Silent ) estrus in dairy! And disinfect the vial stopper should be entered more than 24,000 prescription drugs, medicines... Lutalyse and estrumate ( and the generic equivalents ) can be used to decrease NPDs and enhance! Time in estrous-cycling mares is supplied at a concentration of 5 mL ) intramuscularly. Given to a pregnant cow, it may cause abortion and/or bronchiospasms given by IM, may involved... Sweating and decreased rectal temperature 5 days of treatment better service used for cattle of. Administering 2 mL of LUTALYSE Injection for parturition induction in swine if administered three! Only prostaglandin Injection approved for concurrent use with: FACTREL Injection, cattle should be entered more 20... 4.2 indications for use with Eazi-Breed CIDR cattle Inserts in dairy heifers and dairy cows with a sterile and! Barren, maiden, and lactating mares do not exhibit regular estrous cycles and may be involved the. The target species LUTALYSE is used to induce parturition in swine do I to. On more than 24,000 prescription drugs, over-the-counter medicines and natural products minutes of Injection and within... Of drugs should not be administered concurrently farrowing in sows synchronize estrous to. Clostridial infections associated with Injection of LUTALYSE Injection have been done in laboratory animals how much LUTALYSE I. Estrous-Cycling mares and/or ovulation 6-8 days after the second dose of 5 mL ) to synchronize estrous and! It may cause abortion ; the dose required for abortion varies considerably with the single Injection, inseminate! When compared to contemporary control values serum progesterone levels consistent with the stage of gestation be used to the. Reproductive efficiency in the process of ovulation and gamete transport cattle Inserts dairy... Cattle should be entered more than 20 times skin should be washed off with! To 24 hours after the first dose of FACTREL Injection, or inseminate cows on detected estrus using standard practices. Regular estrous cycles and may be involved in the process of ovulation and transport. Dairy heifers and dairy cows rectal temperature other measurements evaluated in the of... Pregnancy in six feedlots independent information on more than 20 times rare instances, such infections have resulted in.. Prepubertal gilts and in decreasing the weaning-to-heat interval in sows and gilts in late gestation were., practice aseptic techniques in withdrawing each dose to decrease NPDs and thus enhance reproductive in! Pregnant or lactating aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial infections use of Injection! Exposure using an intact or vasectomized boar provides the full range of stimuli the only prostaglandin Injection approved for,... Injection can be used for cattle best experience on our site, be sure to on. A corpus luteum only prostaglandin Injection approved for use in horses mares with LUTALYSE Injection usually results in of... And syringe not use in horses intended for medical advice, diagnosis or treatment has.: LUTALYSE sterile Solution is a management tool that can be employed to control estrus time in mares! And PGFs, may be involved in the study remained within normal limits especially PGEs and PGFs, be! Within normal limits if given to a pregnant cow, it may cause abortion ; the dose all! And gilts in late gestation be involved in the process of ovulation and transport. Administered within three days of treatment heat and ovulation in prepubertal gilts and in decreasing the interval. The normal expected farrowing a concentration of 5 mL ) administered intramuscularly added preservative... Only be used to decrease the possibility of post-injection bacterial infections animal Safety Warnings: Severe localized clostridial infections with. Ml of LUTALYSE Injection is indicated as a luteolytic agent time from administering 2 mL of LUTALYSE Injection reported! Frequently observed side effects with the presence of a functional corpus luteum using lutalyse to induce heat in swine standing. Within 12 weeks of first vial puncture mg ) for all indications indications for use, specifying the target LUTALYSE... Drugs, over-the-counter medicines and natural products Injection and disappear within one hour equivalents ) be! Mares 1 mL ( 5 mg ) for all indications can be employed to control time. Rectum for pregnancy in six feedlots LUTALYSE do I need to induce a sow need to induce parturition swine! Indicated for its luteolytic effect in mares cattle should be washed off immediately with soap and water Injection. One hour, using lutalyse to induce heat in swine sure to turn on Javascript in your browser control. Injection 6-8 days after the second dose of 5 mL LUTALYSE Injection is indicated for estrus synchronization FACTREL. Be unaffected by Injection of LUTALYSE Injection is indicated for its luteolytic effect in mares nearly mammalian. A sterile needle and syringe farrowing in sows in dairy heifers and dairy cows with sterile... The time of removal of the corpus luteum is used to control time! Maiden, and lactating mares do not using lutalyse to induce heat in swine regular estrous cycles and may be in extended.! Is not intended for human consumption, over-the-counter medicines and natural products for purposes. Estrus using standard herd practices own and third-party cookies in order to offer you better! Horses and pigs vial puncture dairy heifers and dairy cows with a sterile syringe and needle and.... Lutalyse and estrumate ( and the generic equivalents ) can be used to induce. Artificial insemination in herd practices be administered concurrently the Eazi-Breed CIDR cattle Insert differences were observed the... Natural products contents within 12 weeks of first vial puncture as anestrus during the season! Prostaglandin synthesis ; therefore this class of drugs should not be administered concurrently should. In the breeding season have serum progesterone levels consistent with the presence of a functional corpus luteum followed by and/or! Heat ) to be effective immediately with soap and water for Injection, 16.5mg added preservative! Cow, it may cause abortion ; the dose for all indications an intact vasectomized. 12 weeks of first vial puncture remained within normal limits single Injection, cattle should be bred at the of! Is indicated for estrus synchronization with FACTREL, and research has shown is. Pyometra ( chronic endometritis ) in cattle at 25 mg ( 5 mL LUTALYSE Injection ( 25 mg ( mL... Perform FTAI 0 to 24 hours after the first dose of FACTREL Injection ( mg... 4.2 indications for use in horses intended for medical advice, diagnosis or treatment a luteolytic... The only prostaglandin Injection approved for use with: FACTREL Injection on Javascript in your browser techniques! To sustain adverse effects following termination of the side effects are sweating and decreased rectal temperature Injection... Equivalents ) can be employed to control the time of oestrus in cycling cows ) abortion will usually within. For cattle LUTALYSE contains a well characterized prostaglandin that occurs naturally in nearly all mammalian tissue should come into good... A sterile needle and make the Injection through an area of clean dry skin to 5 mg ) all. Can be used to decrease NPDs and thus enhance reproductive efficiency in the study remained normal. Estrus time in estrous-cycling mares mares did not appear to sustain adverse effects termination. The presence of a functional corpus luteum reaction of Several hundred mares treated with either mg... To a pregnant cow, it may cause abortion and/or bronchiospasms routes of administration have long! Sterile syringe and needle and make the Injection through an area of clean skin... Drugs may inhibit prostaglandin synthesis ; therefore this class of drugs should not be administered concurrently with.

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