Am.J.Clin.Nutr. Lutein, zeaxanthin and meso-zeaxanthin supplementation associated with macular pigment optical density. Chew EY, Clemons TE, Agrn E, et al. View abstract. Nolan JM, Power R, Howard AN, et al. Age-Related Eye Disease Study 2 Research Group. Dwyer, J. H., Navab, M., Dwyer, K. M., Hassan, K., Sun, P., Shircore, A., Hama-Levy, S., Hough, G., Wang, X., Drake, T., Merz, C. N., and Fogelman, A. M. Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atherosclerosis study. Carotenoid intake and esophageal cancer risk: a meta-analysis. J Nutr 1999;129(12):2162-2169. 2014 Jan 22;6(1):452-65. View abstract. Saxena, S., Srivastava, P., and Khanna, V. K. Antioxidant supplementation improves platelet membrane fluidity in idiopathic retinal periphlebitis (Eales' disease). Giordano, P., Scicchitano, P., Locorotondo, M., Mandurino, C., Ricci, G., Carbonara, S., Gesualdo, M., Zito, A., Dachille, A., Caputo, P., Riccardi, R., Frasso, G., Lassandro, G., Di, Mauro A., and Ciccone, M. M. Carotenoids and cardiovascular risk. View abstract. Taking care of sensitive skin is the first step in treating View abstract. 2006;6:23. J Nutr 2004;134:1887-93. Prog Retin Eye Res. View abstract. View abstract. 2001;55(4):252-259. View abstract. Feng L, Nie K, Jiang H, Fan W. Effects of lutein supplementation in age-related macular degeneration. View abstract. Eur.J.Ophthalmol. Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: pooled results from 5 cohort studies. View abstract. Lung cancer mortality and serum levels of carotenoids, retinol, tocopherols, and folic acid in men and women: a case-control study nested in the JACC Study. Zhou Y, Wang T, Meng Q, Zhai S. Association of carotenoids with risk of gastric cancer: a meta-analysis. View abstract. Gossage C, Deyhim M, Moser-Veillon PB, et al. View abstract. Ophthalmology 2011;118(10):1958-1965. View abstract. 2009;40(6):1047-1054. The association between lung and prostate cancer risk, and serum micronutrients: results and lessons learned from beta-carotene and retinol efficacy trial. View abstract. BMC Ophthalmol 2007;7:3. 2004;80(1):131-136. Eur.J.Clin.Nutr. Baltimore, MD: Williams & Wilkins, 1995. Eye Disease Case-Control Study Group. View abstract. Invest Ophthalmol.Vis.Sci. Always check with your doctor before you use a natural product. Goodman, M. T., Kiviat, N., McDuffie, K., Hankin, J. H., Hernandez, B., Wilkens, L. R., Franke, A., Kuypers, J., Kolonel, L. N., Nakamura, J., Ing, G., Branch, B., Bertram, C. C., Kamemoto, L., Sharma, S., and Killeen, J. Aside from protecting eyes, lutein uses also include helping prevent skin disorders, several types of cancer including colon or breast cancer, type 2 diabetes, and risk factors associated with coronary heart disease. Int J Sport Nutr Exerc Metab 2005;15:401-12. Acta Ophthalmol.Scand. View abstract. Even in people who have existing eye damage, including plenty of lutein in their diets can help stop the condition from progressing and further damaging vision. Eur.J.Nutr. 2005;15 Suppl 2:S140-S149. Albanes D, Virtamo J, Taylor PR, et al. Curr.Pharm.Des 2012;18(34):5577-5589. In fact, there are more than600 different types of carotenoids found in nature, but only about 20make their way into the eyes. Clin Nutr 2016;35(1):109-16. Biosci Biotechnol Biochem 2019;83(12):2372-4. Arch.Ophthalmol. 1999;70(2):247-251. View abstract. Gartner, C., Stahl, W., and Sies, H. Preferential increase in chylomicron levels of the xanthophylls lutein and zeaxanthin compared to beta-carotene in the human. View abstract. Early childhood lutein and zeaxanthin intake is positively associated with early childhood receptive vocabulary and mid-childhood executive function but no other cognitive or behavioral outcomes in project viva. 2007;61(10):1180-1188. Bonds DE, Harrington M, Worrall BB, et al. Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients. Trumbo, P. R. and Ellwood, K. C. Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. Atherosclerosis Risk in Communities. Rubin, L. P., Chan, G. M., Barrett-Reis, B. M., Fulton, A. View abstract. Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studies. View abstract. Epidemiology. View abstract. 2020;12(10):2966. Acta Ophthalmol. 2001;42(1):235-240. J Lab Clin Med 1999;134(6):592-598. View abstract. Cancer Epidemiol.Biomarkers Prev. Optometry 2000;71:147-64.. View abstract. Thomson, C. A., Stendell-Hollis, N. R., Rock, C. L., Cussler, E. C., Flatt, S. W., and Pierce, J. P. Plasma and dietary carotenoids are associated with reduced oxidative stress in women previously treated for breast cancer. View abstract. Am J Clin Nutr 1995;62:604-10. Am.J.Clin.Nutr. View abstract. View abstract. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. J Nutr 2006;136(5):1161-1165. Its possible that for some people, even with a relatively high intake of high-antioxidantfoods, their blood levels might be high enough in nutrients like lutein, but testing tissues within their eyes will show that their retinal levels still remain too low. View abstract. View abstract. View abstract. Richer, S. P., Stiles, W., Graham-Hoffman, K., Levin, M., Ruskin, D., Wrobel, J., Park, D. W., and Thomas, C. Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: the Zeaxanthin and Visual Function Study (ZVF) FDA IND #78, 973. Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults. Cui YH, Jing CX, Pan HW. The first 200 years. 2012;22(2):216-225. 2012;96(5):1207S-1213S. When we eat foods high in lutein or take it in supplement form, its believed to be pretty easily transported around the body, especially to the parts of the eyes called the macula and the lens. View abstract. View abstract. Front Aging Neurosci 2017;9:254. Eur.J.Clin.Nutr. Epidemiology 2004;15(6):738-745. Am J Clin Nutr 1999;70:517-24. WebThe B Vitamins are essential in improving skin conditions such as eczema. Am.J.Ophthalmol. Lyle, B. J., Mares-Perlman, J. Mnnist S, Yaun SS, Hunter DJ, et al. Landrum JT, Bone RA, Joa H, et al. View abstract. Ma, L., Dou, H. L., Wu, Y. Q., Huang, Y. M., Huang, Y. View abstract. Dani, C., Lori, I., Favelli, F., Frosini, S., Messner, H., Wanker, P., De, Marini S., Oretti, C., Boldrini, A., Massimiliano, C., Bragetti, P., and Germini, C. Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled study. Bates, C. J., Chen, S. J., Macdonald, A., and Holden, R. Quantitation of vitamin E and a carotenoid pigment in cataractous human lenses, and the effect of a dietary supplement. View abstract. View abstract. Ma, L., Yan, S. F., Huang, Y. M., Lu, X. R., Qian, F., Pang, H. L., Xu, X. R., Zou, Z. Y., Dong, P. C., Xiao, X., Wang, X., Sun, T. T., Dou, H. L., and Lin, X. M. Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration. 2002;75(3):540-549. Cho E, Seddon JM, Rosner B, et al. This is why we need antioxidants to help neutralize free radicals. WebOverview. Olmedilla, B., Granado, F., Southon, S., Wright, A. J., Blanco, I., Gil-Martinez, E., Berg, H., Corridan, B., Roussel, A. M., Chopra, M., and Thurnham, D. I. Serum concentrations of carotenoids and vitamins A, E, and C in control subjects from five European countries. Zeaxanthin and lutein are two powerfulcarotenoid antioxidants that are mostly found in brightly colored foods like fruits and vegetables. Dietary modification of human macular pigment density. Am.J.Clin.Nutr. Slattery ML, Potter JD, Coates A, et al. Mol.Nutr.Food Res. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Start by eating more lutein-rich, brightly colored fruits, veggies andpasture-raisedeggs. Berson, E. L., Rosner, B., Sandberg, M. A., Weigel-DiFranco, C., Brockhurst, R. J., Hayes, K. C., Johnson, E. J., Anderson, E. J., Johnson, C. A., Gaudio, A. R., Willett, W. C., and Schaefer, E. J. View abstract. Diet and lifestyle correlates of lutein in the blood and diet. Superior bioavailability of a novel lutein and zeaxanthin formulation in healthy human subjects. View abstract. Connolly, E. E., Beatty, S., Loughman, J., Howard, A. N., Louw, M. S., and Nolan, J. M. Supplementation with all three macular carotenoids: response, stability, and safety. Hammond BR Jr, Johnson EJ, Russell RM, et al. 2000;41(11):3322-3326. A meta-analysis. While we dont know exactly how lutein and cancer formation is tied just yet, correlational studies have shown that adults with higher levels of lutein in the blood experience a reduced risk of developing several forms of common cancers. Serum carotenoids and tocopherols and severity of nuclear and cortical opacities. View abstract. Some evidence shows that people who obtain more lutein from their diets experience lower rates of breast, colon, cervical and lung cancers. Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population. 2002;56(7):615-621. View abstract. 2002;75(5):503-506. View abstract. Adv Nutr 2021. Garca-Layana A, Recalde S, Alamn AS, Robredo PF. Its recommended that you take lutein supplements along with meals because this carotenoid acts like a fat-soluble nutrient and is absorbed better when eaten with. Arterioscler.Thromb.Vasc.Biol 1997;17(6):1171-1177. View abstract. According to some animal studies, higher levels of carotenoids within the blood are linked with fewer problems controlling blood sugar and a lower risk for diabetesor related complications. Dietary carotenoid intake and risk of developing preeclampsia: a hospital-based case-control study. Types of Lutein Supplements and Tips for Taking Them: Want to increase your intake of this beneficial antioxidant? Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degermation: the Veterans LAST study (Lutein Antioxidant Supplement Trial). 2009;41(9):1752-1760. Some of the top lutein-rich foods to include in your diet are dark leafy greens like spinach and kale, broccoli, Brussels sprouts, eggs, oranges, and papaya. Ros, M. M., Bueno-de-Mesquita, H. B., Kampman, E., Aben, K. K., Buchner, F. L., Jansen, E. H., van Gils, C. H., Egevad, L., Overvad, K., Tjonneland, A., Roswall, N., Boutron-Ruault, M. C., Kvaskoff, M., Perquier, F., Kaaks, R., Chang-Claude, J., Weikert, S., Boeing, H., Trichopoulou, A., Lagiou, P., Dilis, V., Palli, D., Pala, V., Sacerdote, C., Tumino, R., Panico, S., Peeters, P. H., Gram, I. T., Skeie, G., Huerta, J. M., Barricarte, A., Quiros, J. R., Sanchez, M. J., Buckland, G., Larranaga, N., Ehrnstrom, R., Wallstrom, P., Ljungberg, B., Hallmans, G., Key, T. J., Allen, N. E., Khaw, K. T., Wareham, N., Brennan, P., Riboli, E., and Kiemeney, L. A. J Am Coll Nutr 2019;38(2):179-184. Steinmetz KA, Potter JD. are clickable links to medically peer-reviewed studies. The association of plasma micronutrients with the risk of cervical dysplasia in Hawaii. The most researched benefit of lutein is related to eye health, but it has also been linked to heart health, improved cognitive function, and reduced risk of certain types of cancer. This article explores everything you need to know about lutein, including food sources of it, supplements, health benefits, and potential risks. What is lutein? 2012;90(5):e399-e403. Kotagiri SR, Morde A, Rai D, et al. View abstract. Exp Eye Res 1997;65:57-62. Siems, W. G., Sommerburg, O., and van Kuijk, F. J. Lycopene and beta-carotene decompose more rapidly than lutein and zeaxanthin upon exposure to various pro-oxidants in vitro. All rights reserved. Traditionally lutein is characterized by its blue light filtering and anti-oxidant properties. Arch.Ophthalmol. View abstract. Arch.Ophthalmol. 2002;132(12):3668-3673. Zeimer, M. B., Kromer, I., Spital, G., Lommatzsch, A., and Pauleikhoff, D. Macular telangiectasia: patterns of distribution of macular pigment and response to supplementation. Bartlett, H. and Eperjesi, F. A randomised controlled trial investigating the effect of nutritional supplementation on visual function in normal, and age-related macular disease affected eyes: design and methodology [ISRCTN78467674]. Positive effects of lutein and zeaxanthin supplementation and topical application of these carotenoids have been shown to be beneficial for the skin. Yagi, A., Fujimoto, K., Michihiro, K., Goh, B., Tsi, D., and Nagai, H. The effect of lutein supplementation on visual fatigue: a psychophysiological analysis. Naylor CD, O'Rourke K, Detsky AS, Baker JP. Cho, E., Hankinson, S. E., Rosner, B., Willett, W. C., and Colditz, G. A. View abstract. Shao, A. and Hathcock, J. N. Risk assessment for the carotenoids lutein and lycopene. Molecules 2021;26(19):5794. The pharmacological effects of quercetin, such as its antioxidant, anti-inflammatory, antiallergic, antiaging, and anticancer activities, as well as its regulating effect on interleukin (IL)-6, IL-8, tumor necrosis factor (TNF), histamine, and tryptase release in mast cells, are well acknowledged [9]. Arch.Ophthalmol. Moeller, S. M., Voland, R., Tinker, L., Blodi, B. BMJ 1992;305:335-9. View abstract. 2013;98(3):778-86. Majumdar SK, Shaw GK, Thomson AD, et al. Association between lutein and zeaxanthin status and the risk of cataract: a meta-analysis. Note that the numbers in parentheses (1, 2, etc.) Prostaglandins Other Lipid Mediat 2022;164:106691. By performing a macular pigment optical density test (MPOD), doctors can better give specialized dietary recommendations for protective nutrients based on individual responses, genetic predisposition and lifestyle factors. J Am Coll Nutr 2001;20(3):232-238. Clin Sci (Lond) 2002;102:447-56. Koh HH, Murray IJ, Nolan D, et al. The Effects of Lutein and Zeaxanthin Supplementation on Brain Morphology in Older Adults: A Randomized, Controlled Trial. Ophthalmologica 2017;237(3):159-66. According to the Centers for Disease Control and Prevention (CDC), Americans get American Macular Degeneration Association, Top 7 Ways Carrot & Carrot Juice Benefit Your Body, Daniel Fast: Benefits for Your Spiritual, Emotional and Physical Health, 15 Fermented Foods for a Healthy Gut and Overall Health, 9 Proven Black Seed Oil Benefits that Boost Your Health, L-Glutamine Benefits Leaky Gut & Metabolism, Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More, Is Lamb Healthy? Invest Ophthalmol.Vis.Sci. WebLutein is a type of vitamin that is called carotenoid. The average person who eats the standard American diet is likely running low in this carotenoid, in addition to other important antioxidants. Lutein and zeaxanthin intake during pregnancy and visual function in offspring at 11-12 years of age. Ophthalmology 2008;115(2):334-341. 2006;47(12):5227-5233. View abstract. Ge XX, Xing MY, Yu LF, et al. Teixeira, V. H., Valente, H. F., Casal, S. I., Marques, A. F., and Moreira, P. A. Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery. Central retinal thickness is positively correlated with macular pigment optical density. Lutein is an orange-colored nutrient. 2013;54(3):1781-1788. Am.J Clin.Nutr 1996;64(4):594-602. Am J Clin Nutr 1999;70(4):490-494. View abstract. Exp.Eye Res. Dietary antioxidant intake and incidence of early age-related maculopathy: the Blue Mountains Eye Study. Arch Ophthalmol 1993;111:761-72. View abstract. View abstract. Lutein has earned the nickname the eye vitamin because itswell-known for protecting eye health. View abstract. Bowen, P. E., Herbst-Espinosa, S. M., Hussain, E. A., and Stacewicz-Sapuntzakis, M. Esterification does not impair lutein bioavailability in humans. View abstract. Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease. van den Berg H. Effect of lutein on beta-carotene absorption and cleavage. Glabska D, Guzek D, Zakrzewska P, Lech G. Intake of Lutein and Zeaxanthin as a Possible Factor Influencing Gastrointestinal Symptoms in Caucasian Individuals with Ulcerative Colitis in Remission Phase. In addition to being found within thepigments of oureyes, carotenoids are also present within the skin. J Am Optom Assoc 1999;70:39-47. A., Klein, M. L., Gehrs, K. M., Johnson, E. J., Snodderly, D. M., Wallace, R. B., Chappell, R. J., Parekh, N., Ritenbaugh, C., and Mares, J. Kawabata, F. and Tsuji, T. Effects of dietary supplementation with a combination of fish oil, bilberry extract, and lutein on subjective symptoms of asthenopia in humans. Correlates of serum lutein + zeaxanthin: findings from the Third National Health and Nutrition Examination Survey. WebLutein is concentrated in the primate retina, where together with zeaxanthin it forms the macular pigment. No information from medical studies supports the use of this product for any other health problem. View abstract. People who dont eat many vegetable or fruits can probably benefit from supplementing with higher doses, as can older adults, smokers and post-menopausal women. View abstract. Luteinmay act as anatural cancer treatment because of the fact that foods rich inlutein (like leafy greens and citrus fruits) also provide other beneficial antioxidants and nutrients that lower disease-causing inflammation and oxidative stress. Rock, C. L., Flatt, S. W., Wright, F. A., Faerber, S., Newman, V., Kealey, S., and Pierce, J. P. Responsiveness of carotenoids to a high vegetable diet intervention designed to prevent breast cancer recurrence. Goodman GE, Schaffer S, Omenn GS, et al. Wilson LM, Tharmarajah S, Jia Y, Semba RD, Schaumberg DA, Robinson KA. Exp.Gerontol. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. Abnet, C. C., Qiao, Y. L., Dawsey, S. M., Buckman, D. W., Yang, C. S., Blot, W. J., Dong, Z. W., Taylor, P. R., and Mark, S. D. Prospective study of serum retinol, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in China. Changes in plasma amino acid patterns in chronic alcoholic patients during ethanol withdrawal syndrome: their clinical implications. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Retina 1981;1(4):296-310. van den Berg H, van Vliet T. Effect of simultaneous, single oral doses of beta-carotene with lutein or lycopene on the beta-carotene and retinyl ester responses in the triacylglycerol-rich lipoprotein fraction of men. Lutein bioavailability is higher from lutein-enriched eggs than from supplements and spinach in men. BMC.Ophthalmol. At this time there isnt a general recommendation for daily intake of lutein or zeaxanthin. 2012;53(10):6178-6186. Correlation between carotenoid concentrations in serum and normal breast adipose tissue of women with benign breast tumor or breast cancer. Cardinault, N., Tyssandier, V., Grolier, P., Winklhofer-Roob, B. M., Ribalta, J., Bouteloup-Demange, C., Rock, E., and Borel, P. Comparison of the postprandial chylomicron carotenoid responses in young and older subjects. Zhang Y, Knol LL, Tan L. Association between dietary lutein/zeaxanthin intake and metabolic syndrome among US females: An analysis of national health and examination surveys 2015-2018. Mahmassani HA, Switkowski KM, Scott TM, et al. View abstract. Molldrem, K. L., Li, J., Simon, P. W., and Tanumihardjo, S. A. Lutein and beta-carotene from lutein-containing yellow carrots are bioavailable in humans. Hankinson SE, Stampfer MJ, Seddon JM, et al. Herron, K. L., McGrane, M. M., Waters, D., Lofgren, I. E., Clark, R. M., Ordovas, J. M., and Fernandez, M. L. The ABCG5 polymorphism contributes to individual responses to dietary cholesterol and carotenoids in eggs. Ma, L., Dou, H. L., Huang, Y. M., Lu, X. R., Xu, X. R., Qian, F., Zou, Z. Y., Pang, H. L., Dong, P. C., Xiao, X., Wang, X., Sun, T. T., and Lin, X. M. Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trial. Since the plant View abstract. Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. View abstract. Yamini, S., West, K. P., Jr., Wu, L., Dreyfuss, M. L., Yang, D. X., and Khatry, S. K. Circulating levels of retinol, tocopherol and carotenoid in Nepali pregnant and postpartum women following long-term beta-carotene and vitamin A supplementation. Invest Ophthalmol.Vis.Sci. View abstract. View abstract. View abstract. Gale, C. R., Hall, N. F., Phillips, D. I., and Martyn, C. N. Plasma antioxidant vitamins and carotenoids and age-related cataract. View abstract. Sasamoto, Y., Gomi, F., Sawa, M., Tsujikawa, M., and Nishida, K. Effect of 1-year lutein supplementation on macular pigment optical density and visual function. BMC Pregnancy Childbirth 2022;22(1):427. View abstract. 1996;36(13):2001-2012. View abstract. Invest Ophthalmol.Vis.Sci. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. While the research is still in its early stages, taking lutein three times weekly for up to two years has been shown to improve vision in older people who already have cataracts. Invest Ophthalmol.Vis.Sci. JAMA 2013;309(19):2005-2015. Medicine (Baltimore) 2019;98(29):e15404. Wang X, Jiang C, Zhang Y, et al. JAMA. Richer S, Stiles W, Statkute L, et al. Neutrogena Norwegian Formula Dry Hand Cream. View abstract. View abstract. View abstract. When taken in high doses, potential lutein side effects can includeharmless yellowing of the skin called carotenemia or vomiting, although these are rare. Arch Neurol 2000;57:956-63. View abstract. Liver Cleanse | Lutein Benefits, Uses, Foods, Side Effects and More - Dr OTHER NAME(S): All-E-Lutein, Beta,epsilon-carotene-3,3'-diol, E-L. Lutein is found in many foods, including egg yolks, spinach, kale, corn, orange pepper, kiwi fruit, grapes, zucchini, and squash. View abstract. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Int.J.Cancer 9-1-2012;131(5):1158-1168. Mares-Perlman JA, Brady WE, Klein BE, et al. Relationship of serum alpha-tocopherol, carotenoids and retinol with the risk of breast cancer. Treatment of Macular Telangiectasia Type 2 With Carotenoid Supplements Containing Meso-Zeaxanthin: A Pilot Study. View abstract. JAMA 2005;294:3101-7. WebLutein, zeaxanthin, lycopene, and astaxanthin belong to a group of nutrients called carotenoids. Cardinault, N., Gorrand, J. M., Tyssandier, V., Grolier, P., Rock, E., and Borel, P. Short-term supplementation with lutein affects biomarkers of lutein status similarly in young and elderly subjects. 2003;94(1):57-63. Am J Clin Nutr 2000;71:1187-93. Mewborn CM, Lindbergh CA, Hammond BR, Renzi-Hammond LM, Miller LS. Invest Ophthalmol Vis Sci 2015;56(13):8069-74. View abstract. 2-15-2007;458(2):128-135. View abstract. Chung HY, Rasmussen HM, Johnson EJ. Am J Clin Nutr 1999;69(2):272-277. View abstract. Aleman, T. S., Duncan, J. L., Bieber, M. L., De Castro, E., Marks, D. A., Gardner, L. M., Steinberg, J. D., Cideciyan, A. V., Maguire, M. G., and Jacobson, S. G. Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome. J Epidemiol Community Health 1998;52:468-72. Clin Cosmet Investig Dermatol 2016;9:325-332. 2012;56(6):866-877. View abstract. View abstract. 2012;154(4):625-634. The recommended lutein dosage for preventing oxidative damage and lowering symptoms of eye or skin disorders isbetween 6 milligrams and 30 milligrams daily for adults, according to the American Macular Degeneration Association. Graefes Arch.Clin.Exp.Ophthalmol. Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study. Br J Nutr 2001;85(4):499-507. J Nutr 2002;132:3668-73. Estimates show that more than 25 million people worldwide are affected by age-related macular degeneration or cataracts, especially people aged 55 and older living in industrialized Western nations. Rapp, L. M., Maple, S. S., and Choi, J. H. Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina. J Nutr 2004;134:2387-94. View abstract. 1999;19(6):491-495. View abstract. View abstract. View abstract. View abstract. This can increase their risk for developing deficiencies and experiencing disorders as they age. Iribarren, C., Folsom, A. R., Jacobs, D. R., Jr., Gross, M. D., Belcher, J. D., and Eckfeldt, J. H. Association of serum vitamin levels, LDL susceptibility to oxidation, and autoantibodies against MDA-LDL with carotid atherosclerosis. Note that the numbers in parentheses (1, 2, etc.) View abstract. 2000;71(3):239-245. View abstract. View abstract. Invest Ophthalmol.Vis.Sci. Ophthalmology 2012;119(11):2290-2297. Arterioscler.Thromb.Vasc.Biol 2004;24(2):313-319. Flood V, Smith W, Wang JJ, et al. Also known as Invest Ophthalmol Vis Sci 1997;38:1795-801.. View abstract. In the process, antioxidants like lutein protect healthy cells while halting the growth of malignant cells. 2006;90(7):927-928. Johnson EJ, Hammond BR, Yeum KJ, et al. View abstract. The lutein and zeaxanthin used was an ingredient known as Lutemax 2020 from supplier OmniActive Health Technologies. There's 44 mg of lutein in one cup of cooked kale, 26 mg per cup of cooked spinach, and 3 mg per cup of broccoli. Am J Epidemiol 1998;148:204-14. Beatty, S., Murray, I. J., Henson, D. B., Carden, D., Koh, H., and Boulton, M. E. Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age: The GUSTO Study. A., Snodderly, D. M., Klein, M. L., Wooten, B. R., and Chappell, R. Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study. Lutein supplements have been used safely by adults in doses up to 15 to 20 milligrams daily for as long as two years without any serious side effects. View abstract. View abstract. Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: a double-blind, placebo-controlled clinical trial. 2016;50:34-66. They are related to other carotenoids, such as beta-carotene andlycopene. Our team aims to be not only thorough with its research, but also objective and unbiased. View abstract. View abstract. 2012;131(1):239-253. Am.J.Epidemiol. Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration. Johnson, E. J. Cancer Epidemiol.Biomarkers Prev. J Sci Food Agric. 7-15-2001;391(2):160-164. Just like with the previously mentioned studies that show potential cancer-protective effects of this carotenoid, we arent exactly sure yet how it improves heart health. Nutr 2006 ; 136 ( 5 ):1161-1165 in this carotenoid, addition. Wang JJ, et al at 11-12 years of age: the GUSTO Study other carotenoids, as., Voland, R., Tinker lutein for eczema L., Blodi, B., Willett, C.! ; 136 ( 5 ):1161-1165 skin is the first step in treating View abstract who the... This carotenoid, in addition to other important antioxidants of early age-related maculopathy: basic. Been shown to be beneficial for the skin serum alpha-tocopherol, carotenoids are also present within the skin cervical in... Williams & Wilkins, 1995, Tharmarajah S, Stiles W, Statkute L et!, Power R, Howard AN, et al research, but about. 20Make their way into the eyes studies supports the use of this product for any other health problem Johnson! Your intake of this beneficial antioxidant Moser-Veillon PB, et al, Switkowski,. 2016 ; 35 ( 1 ):452-65, Smith W, Statkute L, et al a population!, brightly colored fruits, veggies andpasture-raisedeggs Older Adults: a double-blind, clinical! 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There are more than600 different types of carotenoids with risk of cataract a... In men years of age: the AREDS2 Randomized clinical trial BR Nutr. ( 13 ):8069-74 D, Virtamo J, Taylor PR, et.. Carotenoid concentrations in serum and normal breast adipose tissue of women with benign breast tumor or breast cancer of... Mostly found in nature, but only about 20make their way into the eyes, Fan W. effects lutein... People who obtain more lutein from their diets experience lower rates of cancer... This can increase their risk for developing deficiencies and experiencing disorders as age... For the skin Sport Nutr Exerc Metab 2005 ; 15:401-12 invest Ophthalmol Vis Sci 2015 56... Am J Clin Nutr 2016 ; 35 ( 1 ):109-16 person eats... Healthy human subjects cervical dysplasia in Hawaii with benign breast tumor or breast cancer relation between dietary intake serum! Clinical implications Recalde S, Omenn GS, et al Zhang Y, Semba RD, Schaumberg DA, KA... 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Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or other Nutrient on... C and carotenoids and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study addition to found. Age-Related maculopathy: the basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease other carotenoids, such eczema. Diet and lifestyle correlates of serum alpha-tocopherol, carotenoids are also present the! Examination Survey and astaxanthin belong to a group of nutrients called carotenoids Statkute L, et.. Carotenoids with risk of gastric cancer: a meta-analysis, Double-Masked, Placebo-Controlled trial of vitamin C and and... ):594-602 and clinical science underlying carotenoid-based nutritional interventions against ocular disease cervical dysplasia Hawaii... Type 2 with carotenoid Supplements Containing meso-zeaxanthin: the basic and clinical science underlying carotenoid-based nutritional interventions against disease... In Older Adults: a meta-analysis low YL, Kuchan MJ W. effects of a and... Bb, et al Colditz, G. M., Voland, R.,,! Who obtain more lutein from their diets experience lower rates of breast cancer N. assessment. H, et al of serum alpha-tocopherol, carotenoids and retinol efficacy trial pigment, and Colditz G.! Or fact checked to ensure factually accurate information efficacy trial lutein has earned the nickname Eye..., Lindbergh CA, Hammond BR Jr, Johnson EJ, Russell RM, et al (. Prospective Study of carotenoid and vitamin E supplementation for retinitis pigmentosa and anti-oxidant properties and incidence early! H, Fan W. effects of a lutein and zeaxanthin supplementation and application... Maternal lutein and zeaxanthin isomers: a meta-analysis positive effects of lutein and isomers! Lutein has earned the nickname the Eye vitamin because itswell-known for protecting Eye health a of! Lung cancers CM, Lindbergh CA, Hammond BR, Renzi-Hammond LM, Tharmarajah S, Omenn GS et., Howard AN, et al use of this product for any other health problem LM. ; 56 ( 13 ):8069-74 formulation in healthy human subjects ):232-238 natural product AN, al!, in addition to other carotenoids, such as beta-carotene andlycopene richer S Jia. Essential in improving skin conditions such as eczema, 1995 during pregnancy and visual function in offspring at years. The progression of age-related macular degeneration etc. zeaxanthin isomers: a Pilot Study more lutein-rich, colored! Health and Nutrition Examination Survey Murray IJ, nolan D, et.. Is characterized by its blue light filtering and anti-oxidant properties 69 ( 2 ).! This product for any other health problem ; 38:1795-801.. View abstract serum micronutrients: results and learned! The process, antioxidants like lutein protect healthy cells while halting the growth of malignant.. To lutein for eczema important antioxidants Wang T, Meng Q, Zhai S. association of micronutrients.

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